The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function
Authors' conclusion
Although in patients with obesity, six months after bariatric surgery systemic inflammatory markers and leukocyte numbers are decreased to the levels observed in healthy lean subjects, there is still a residual functional and transcriptional hyper-inflammatory monocyte phenotype. This might be caused, at least in part, by the capacity of adipose tissue to induce long-term pro-inflammatory effects in monocytes. These finding help to understand the long-term effects of obesity and bariatric surgery on cardiovascular health.
Study context
- Population
- Patients with obesity undergoing bariatric surgery; healthy normal-weight controls
- Participants
- 27 vs 20
- Exposure
- Patients with obesity before vs 6 months after MBS, vs healthy normal-weight subjects
- Obesityn = 27
- Healthyn = 20reference
- Outcome
- Innate immune cell (monocyte) phenotype and function after MBS
- Follow-up
- Six months after bariatric surgery
Methodological detailsex vivo models, in vitro studies
- Ex vivo models
- In vitro studies
Main finding
As reported in the abstract
- Leukocyte numbers and systemic inflammatory markers such as hs-CRP decreased after MBS to the level of normal-weight controls
- Hyperresponsive pro-inflammatory monocyte phenotype only partially reverted 6 months after MBS, aligned with RNA expression profiles
Observational data: associations, not effects.
Further findings
In vitro: healthy donor monocytes exposed 24 h to adipose tissue from patients with obesity · one week
- Exposure to adipose tissue induces a persistent augmented cytokine production capacity
Original publication
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