The impact of medroxyprogesterone acetate on lipid profiles in Women: A time and dose-response meta-analysis of randomized controlled trials
Authors' conclusion
The current meta-analysis showed a statistically significant decrease in TC, TG, and HDL-C levels and a non-significant increase in LDL-C levels after MPA administration in women.
Study context
- Population
- Women; RCTs from Web of Science, Scopus, PubMed/Medline and Embase up to October 20, 202335 studies · 58 arms
- Comparison
- MPA vs control
- Outcome
- Lipid profile (TC, HDL-C, triglyceride (TG))
Methodological detailsrandom-effects (DerSimonian and Laird), time and dose-response
- Random-effects (DerSimonian and Laird)
- Time and dose-response
Pooled result
As reported in the abstract
Lipid profile
Estimate (95 % CI)P value
MPAvs Control
WMD (TC) −3.43 mg/dL(−5.38 to −1.48)
P < 0.001MPAvs Control
WMD (HDL-C) −3.34 mg/dL(−3.77 to −2.91)
P < 0.001MPAvs Control
WMD (TG) −9.13 mg/dL(−10.92 to −7.33)
P < 0.001Further pooled results
Total cholesterol (TC) by subgroup
mg/dL
- Dosage > 2.5 mg/day, WMD
- −4.10
- Mean age <60 years, WMD
- −3.80
- Mean BMI <25 kg/m², WMD
- −5.61
- Intervention ≥12 months, WMD
- −3.98
- Baseline TC ≥200 mg/dL, WMD
- −4.13
- More substantial TC reduction in these subgroups
LDL-C
- Non-significant increase in LDL-C after MPA
Original publication
The impact of medroxyprogesterone acetate on lipid profiles in Women: A time and dose-response meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 22 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →