Maintaining the gluten-free diet: The key to improve glycemic metrics in youths with type 1 diabetes and celiac disease
Authors' conclusion
Individuals with T1D and CD who maintain GFD presented similar glucose metrics compared to youths with T1D only. Individuals not strictly maintaining GFD presented higher hyperglycemia rates.
Study context
- Population
- Youths aged 8–18 years with T1D, with or without celiac disease, using real-time continuous glucose monitoring (CGM)
- Participants
- 86 vs 167
- Comparison
- Youths with T1D and celiac disease (CD) vs T1D only
- T1D and CDn = 86
- T1D onlyn = 167reference
- Outcome
- Time in range and other CGM metrics with real-time CGM
Methodological detailsobservational, gluten-free diets (GFD) maintenance assessed by anti-tissue transglutaminase antibodies and dietary interview; Mediterranean diet by KIDMED questionnaire
- Observational
- GFD maintenance assessed by anti-tissue transglutaminase antibodies and dietary interview; Mediterranean diet by KIDMED questionnaire
Main finding
As reported in the abstract
Real-time CGM metrics
- The two groups reported similar real-time CGM metrics
Observational data: associations, not effects.
Further findings
| Outcome | T1D only | P value |
|---|---|---|
| % TAR in T1D and CD not completely maintaining GFD (29% of T1D and CD) vs T1D only | 34.34 ± 20.94 % | P = 0.039 |
- % TAR in T1D and CD not completely maintaining GFD (29% of T1D and CD) vs T1D only: T1D and CD not completely maintaining GFD 38.72 ± 20.94 %
- % TAR in T1D and CD not completely maintaining GFD (29% of T1D and CD) vs T1D only: higher hyperglycemia rates with not completely maintaining GFD
Original publication
Maintaining the gluten-free diet: The key to improve glycemic metrics in youths with type 1 diabetes and celiac disease. Diabetes Res Clin Pract. Published 22 December 2023. doi:10.
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