The impact of facility type and volume on treatment and overall survival in craniopharyngioma
Authors' conclusion
Treatment of craniopharyngioma at HVC compared to LVC is associated with improved OS, lower 30- and 90-day postoperative mortality risk, and more common use of both radiotherapy and endoscopic surgical approach.
Study context
- Population
- Patients diagnosed with craniopharyngioma, National Cancer Database (NCDB) 2004–2016; 51.3% female, mean age 41.2 ± 22.0
- Participants
- 3,730 patients
- Exposure
- High-volume center vs low-volume center
- High-volume center (HVC)n = 2,564
- Outcome
- OS
- Follow-up
- 5-year
Methodological detailsNational Cancer Database (NCDB) 2004-2016
- National Cancer Database (NCDB) 2004-2016
Main finding
As reported in the abstract
Hazard ratio (mortality)
0.69
95% CI 0.56–0.84
By group
Observational data: associations, not effects.
Further findings
Overall survival (OS), whole cohort · 5-year
- Estimated 5-year OS
- 94.8% (94.0-95.5%)
Treatment
- HVC patients treated at academic facilities
- 2142 (83.5%)
- Patients at HVC more likely to undergo both surgery and radiation
- Surgical approach at HVC more likely endoscopic
Postoperative mortality · 30- and 90-day
- Lower 30- and 90-day postoperative mortality risk at HVC vs low-volume center (LVC)
Original publication
The impact of facility type and volume on treatment and overall survival in craniopharyngioma. Pituitary. Published 17 October 2023. doi:10.
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