The impact of diabetes on Sepsis-induced cardiomyopathy
Authors' conclusion
Diabetes exacerbates inflammatory and immune responses in Sepsis-induced cardiomyopathy patients, leading to worsened cardiac function.
Study context
- Population
- Patients with sepsis-induced cardiomyopathy (SIC), stratified by diabetes status and HbA1c levels
- Participants
- 258 patients
- Exposure
- Diabetes vs no diabetes; HbA1c levels
- Outcome
- Inflammatory, immune and cardiac markers by diabetes status
Main finding
As reported in the abstract
- Diabetes worsened inflammation and immune responses in SIC, significantly affecting LVEF, TnI, CK-MB, BNP, NLR, IL-6, PCT, CRP, APACHE II and SOFA scores
- P < 0.05
Observational data: associations, not effects.
Further findings
Markers by HbA1c level
- No significant difference in LVEF
- P = 0.078
- No significant difference in Alb
- P = 0.105
- No significant difference in L/A
- P = 0.211
- Differences in TnI, CK-MB, BNP, NLR, IL-6, PCT, CRP, APACHE II and SOFA
- P < 0.05
Correlation of HbA1c with CRP
- Spearman rs
- 0.8664
Risk factors for SIC (logistic regression)
- BNP OR
- 1.001
- HbA1c OR
- 1.302
- Nomogram AUC
- 0.693
Interaction between HbA1c and BNP on SIC severity
- No significant interaction
- P = 0.791
Original publication
The impact of diabetes on Sepsis-induced cardiomyopathy. Diabetes Res Clin Pract. Published 16 January 2025. doi:10.
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