The Endocrine Phenotype Induced by Pediatric Adrenocortical Tumors Is Age- and Sex-Dependent
Authors' conclusion
The endocrine phenotype induced by pediatric ACT is age- and sex-dependent.
Study context
- Population
- Children and adolescents with adrenocortical tumors (ACT) registered with the GPOH-MET studies, 1997–2022110 female, 45 male
- Participants
- 155 children
- Exposure
- Prepubertal girls vs Pubertal females vs Prepubertal boys vs Pubertal males
- Prepubertal girlsn = 63
- Pubertal femalesn = 47
- Prepubertal boysn = 34
- Pubertal malesn = 11
- Outcome
- Endocrine manifestations of adrenal hormone excess by age and sex
Methodological detailsregistry-based (GPOH-MET studies)
- Registry-based (GPOH-MET studies)
Main finding
As reported in the abstract
Most frequent endocrine manifestations
- Prepubertal girls: pubarche
- 68.3%
- Prepubertal girls: clitoral hypertrophy
- 49.2%
- Prepubertal girls: weight gain
- 31.7%
- Pubertal females: excessive pubic hair
- 46.8%
- Pubertal females: acne
- 36.2%
- Pubertal females: hypertension
- 36.2%
- Prepubertal boys: pubarche
- 55.9%
- Prepubertal boys: penile growth
- 47.1%
- Prepubertal boys: acne
- 32.4%
- Pubertal males: weight gain
- 45.5%
- Pubertal males: hypertension
- 36.4%
- Pubertal males: excessive pubic hair
- 27.3%
- Pubertal males: cushingoid appearance
- 27.3%
Observational data: associations, not effects.
Further findings
- Median age at ACT diagnosis, years [range]
- 4.2 [0.1-17.8]
- Median interval from first symptoms, months [range]
- 4.2 [0-90.7]
Original publication
The Endocrine Phenotype Induced by Pediatric Adrenocortical Tumors Is Age- and Sex-Dependent. J Clin Endocrinol Metab. Published 6 February 2024. doi:10.
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