The effects of glucose-dependent insulinotropic polypeptide on net splanchnic blood flow in lean humans
Authors' conclusion
Under the applied conditions, GIP does not appear to play a substantial role in the acute regulation of net SBF, either alone or in combination with induced hyperglycemia and hyperinsulinemia.
Study context
- Population
- Healthy, lean male participants4 conditions each
- Participants
- 8 participants
- Comparison
- GIP vs saline infusion, alone or with hyperglycaemic hyperinsulinaemic clamp
- GIPn = 8
- Salinen = 8reference
- GIP + clampn = 8
- Saline + clampn = 8
- Primary endpoint
- Splanchnic blood flow (Fick's Principle, hepatic vein catheterization, indocyanine green)
Methodological detailsrandomized, controlled
- Randomized
- Controlled
Primary result
As reported in the abstract
Splanchnic blood flow
- Splanchnic blood flow (SBF) comparable across all conditions, GIP and saline, with and without clamp (P = .42)
Original publication
The effects of glucose-dependent insulinotropic polypeptide on net splanchnic blood flow in lean humans. J Clin Endocrinol Metab. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →