The Effects of 5 Years of Growth Hormone Treatment on Growth and Body Composition in Patients with Temple Syndrome
Authors' conclusion
GH treatment in patients with TS14 normalizes height SDS and improves body composition. There were no adverse effects or safety concerns during GH treatment.
Study context
- Population
- Children with Temple syndrome (TS14) treated with growth hormone (GH)
- Participants
- 13 vs 5
- Exposure
- Height and body composition before vs during 5 years of GH treatment
- Entiren = 13
- Prepubertaln = 5
- Outcome
- Height SDS
- Follow-up
- 5 years of GH treatment
Methodological detailssubgroup analysis of prepubertal children
- Subgroup analysis of prepubertal children
Main finding
As reported in the abstract
- Mean height SDS increased significantly from −1.78 (95% CI −2.52; −1.04) to 0.11 (95% CI −0.66; 0.87)
- Entire group
Observational data: associations, not effects.
Further findings
Body composition
- Fat mass percentage SDS decreased significantly during the first year of GH
- Lean body mass (LBM) SDS and LBM index increased significantly during 5 years of treatment
- Entire group
IGF-1 and IGF-BP3
- IGF-1 and IGF-BP3 rose rapidly; IGF-1/IGF-BP3 molar ratio remained relatively low
Height SDS, LBM SDS and LBM index in prepubertal subgroup
- Median height SDS, LBM SDS and LBM index also increased
Resting energy expenditure (REE) · 1 year
- REE was normal at start and did not change during 1 year of treatment
Adult height SDS
- Patients reaching adult height
- 5
- Median (IQR) adult height SDS
- 0.67 (−1.83; −0.01)
Safety
Safety laboratory parameters
- Thyroid hormone levels, fasting serum glucose and insulin levels remained normal
- No adverse effects or safety concerns during GH treatment
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Effects of 5 Years of Growth Hormone Treatment on Growth and Body Composition in Patients with Temple Syndrome. Horm Res Paediatr. Published 28 March 2023. doi:10.
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