The effect of HbA1c variability on the efficacy of intensive blood pressure control in patients with type 2 diabetes
An erratum to this article was published (Diabetes Obes Metab, May 2025 ↗)
Primary result · Primary composite outcome (nonfatal MI, stroke, CV death), intensive BP control effect by HbA1c variability groupResult — go to the resultHazard ratio 0.60 95% CI 0.40–0.90Authors' conclusion
HbA1c variability had effect on the efficacy of intensive BP control and intensive BP control brought a significant macrovascular benefit in patients with type 2 diabetes and low HbA1c variability.
Study context
- Population
- Patients with T2D in the ACCORD-BP trial
- Comparison
- Intensive blood pressure (BP) control vs standard BP control, by HbA1c variability group
- Primary endpoint
- Composite of:
- Nonfatal MI
- Stroke
- CV death
Methodological detailssubgroup analysis, K-means clustering by HbA1c variability score and baseline HbA1c
- Subgroup analysis
- K-means clustering by HbA1c variability score and baseline HbA1c
Primary result
As reported in the abstract
Primary composite outcome (nonfatal MI, stroke, CV death), intensive BP control effect by HbA1c variability group
Hazard ratio
0.60
95% CI 0.40–0.90
p interaction was 0.03
Intensive BP controlvs standard BP control, by HbA1c variability group
HR 0.60 (95% CI 0.40–0.90); p interaction was 0.03
Further findings
Non-fatal myocardial infarction (MI), low HbA1c variability
| HR (95% CI) | P value | ||
|---|---|---|---|
| Intensive BP control (low HbA1c variability) | 0.61 (0.37–1.00) | p interaction was 0.04 | |
| 0.20.5125Hazard ratio (log scale) |
Stroke, low HbA1c variability
| HR (95% CI) | P value | ||
|---|---|---|---|
| Intensive BP control (low HbA1c variability) | 0.19 (0.05–0.64) | p interaction was 0.02 | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| CV and all-cause mortality | P for interaction > 0.05 |
CV and all-cause mortality
- Intensive BP control did not reduce CV or all-cause mortality in any variability group, on relative and absolute scales
Original publication
The effect of HbA1c variability on the efficacy of intensive blood pressure control in patients with type 2 diabetes. Diabetes Obes Metab. Published 3 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →