The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review
Authors' conclusion
Acromegaly associated structural and functional myocardial changes improve with both medical and surgical treatment. Normalizing or even reducing growth hormone/insulin-like growth factor 1 levels may be key in the prevention of further progression of cardiac involvement in acromegaly and adverse cardiac outcomes.
Study context
- Population
- Patients with acromegaly; studies published up to February, 25, 20229 case reports
- Participants
- 26 patients17 cohort studies
- Comparison
- Cardiac parameters after first GH-lowering intervention
- Outcome
- Cardiac structure (LVH, LVM/LVMi) and cardiac function (LVEF, E/A ratio)
Methodological detailsRisk of bias assessed with modified Newcastle-Ottawa Scale and Joanna Briggs Institute Critical Appraisal Checklist
- Risk of bias assessed with modified Newcastle-Ottawa Scale and Joanna Briggs Institute Critical Appraisal Checklist
Pooled result
As reported in the abstract
Cardiac structure and function after primary treatment
LVM/LVMi significantly decreased
9/15 studies
Prevalence of LVH significantly decreased
3/13 studies
LVEF significantly increased
9/14 studies
E/A ratio significantly increased
6/7 studies
Further pooled results
Cardiac structure by biochemical remission
- Cardiac structure improved more with biochemical remission than without (limited number of studies)
Risk of bias
- Low risk
- 24 studies
- Intermediate risk
- 2 studies
Original publication
The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review. Eur J Endocrinol. Published 29 January 2025. doi:10.
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