Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia
Authors' conclusion
We demonstrate a slight increase in plasma urea levels in response to arginine, but plasma urea and copeptin levels were weakly correlated. Based on these findings, the stimulatory effect of arginine on AVP cannot be explained primarily by increasing urea levels.
Study context
- Population
- Healthy adults and patients with AVP deficiency (AVP-D) or primary polydipsia undergoing arginine stimulation (L-arginine-hydrochloride 21%, 0.5 g/kg over 30 min)
- Participants
- 30 / 69 / 89
- Comparison
- Arginine stimulation test in healthy adults (HA), AVP-D and PP
- HAn = 30
- AVP-Dn = 69
- PPn = 89
- Primary endpoint
- Urea dynamics in response to arginine administration and its effect on copeptin release
Methodological detailspooled data from two prospective diagnostic studies
- Pooled data from two prospective diagnostic studies
Primary result
As reported in the abstract
Change in plasma urea from baseline · 60 min after arginine infusion
HA
+ 1.1
median · IQR + 0.8, + 1.5 · mmol/L
AVP-D
+ 1.4
median · IQR + 1.1, + 1.7 · mmol/L
PP
+ 1.3
median · IQR + 0.9, + 1.5 · mmol/L
Further findings
| Outcome | HA | AVP-D | PP |
|---|---|---|---|
| Change in plasma copeptin from baseline · 60 min | median + 5.3 (IQR + 3.2, + 8.8) pmol/L | median + 0.3 (IQR + 0.1, + 0.6) pmol/L | median + 2.4 (IQR + 1.2, + 3.8) pmol/L |
| Correlation of plasma urea and copeptinHA rho at baseline | Spearman's rho 0.41 | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
- Correlation of plasma urea and copeptin — AVP-D and PP: only weak correlations, coefficient between 0.01 and 0.28
- 0.01–0.28
Original publication
Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia. Pituitary. Published 25 January 2025. doi:10.
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