Selective resection of the medial wall of the cavernous sinus in pituitary surgery: results of a prospective single center analysis
Authors' conclusion
Resection of the MWCS is an effective strategy for improving surgical outcomes in pituitary adenomas with potential invasion into this area, especially in patients with functional and/or recurrent adenomas. The procedure demonstrates a positive balance of efficacy and safety, when performed by teams with high level of experience in endoscopic skull base surgery and in selected patients.
Study context
- Population
- Patients with pituitary adenomas undergoing endoscopic endonasal surgery with selective medial wall of the cavernous sinus (MWCS) resection, Mayo Clinic, Jacksonville
- Participants
- 26 patients
- Outcome
- Surgical outcomes after selective MWCS resection
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Tumor invasion of MWCS confirmed
- 76.9%
- Confirmed MW invasion in acromegaly (highest)
- 88.8%
- Initial disease control
- 88.5%
- Remission at last follow-up, acromegaly
- 87.5%
- Remission at last follow-up, Cushing's disease
- 83.3%
- Remission at last follow-up, prolactinomas
- 66.6%
- Complete resection, nonfunctioning adenomas
- 5/5
Observational data: associations, not effects.
Further findings
Case characteristics
- Functional adenomas and macroadenomas
- 80.8%
- Recurrent adenomas
- 19.2%
Safety
Complications
- There were no carotid injuries, cranial deficits or fatalities observed
Original publication
Selective resection of the medial wall of the cavernous sinus in pituitary surgery: results of a prospective single center analysis. Pituitary. Published 25 January 2025. doi:10.
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