The association of low muscle mass with prevalence and incidence of type 2 diabetes in different BMI classes
Authors' conclusion
Both a low muscle mass and loss of muscle mass are associated with the prevalence and incidence of diabetes in the general population. This association is strongest in people with normal weight, and weakens in people within higher BMI subgroups.
Study context
- Population
- Adult participants of the Lifelines cohort study; men and women of normal weight, overweight or obesity
- Exposure
- Low muscle mass vs not low muscle mass
- Outcome
- Prevalence and incidence of T2D
Methodological detailspopulation-based (Lifelines cohort), multivariate logistic regression
- Population-based (Lifelines cohort)
- Multivariate logistic regression
Main finding
As reported in the abstract
Men: muscle mass and prevalence of T2D, OR (95% CI 1.32-1.72); P < 0.001
1.51
Women: muscle mass and prevalence of T2D, OR (1.36 - 1.73); P < 0.001
1.53
Men: decreased muscle mass and incident T2D, OR (1.05 - 1.43); P = 0.01
1.22
Women: decreased muscle mass and incident T2D, OR (1.17 - 1.59); P < 0.001
1.36
Observational data: associations, not effects.
Further findings
Incident T2D, normal-weight women, after adjustments
- OR (1.16-2.70); P = 0.008; remained significant after adjustments
- 1.77
Original publication
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