The association between gut hormones and diet‐induced metabolic flexibility in metabolically healthy adults
Authors' conclusion
Increased GLP-1 concentration following high-carbohydrate overfeeding associated with a greater shift to carbohydrate oxidation, suggesting that GLP-1 may be implicated in diet-induced metabolic flexibility to carbohydrate overload.
Study context
- Population
- Healthy volunteers with normal glucose regulationcrossover
- Participants
- 69 volunteers
- Comparison
- Fasting and three overfeeding diets vs eucaloric feeding
- Outcome
- Association of fasting GLP-1 and PYY concentrations with metabolic flexibility (change in 24-h RQ from EBL)
Methodological detailswhole-room indirect calorimeter
- Whole-room indirect calorimeter
Main finding
As reported in the abstract
High-carbohydrate overfeeding: increased GLP-1 associated with increased respiratory quotient (RQ)
r = 0.44
p < 0.001
High-carbohydrate overfeeding: increased GLP-1 associated with higher carbohydrate and lower lipid oxidation rates
r = 0.34 and r = −0.51
both p < 0.01
High-carbohydrate overfeeding: increased GLP-1 associated with increased plasma insulin
r = 0.38
p = 0.02
Further findings
24-h RQ change vs EBL
- High-fat overfeeding: 24-h RQ decreased
- ≈4%
- Standard overfeeding: 24-h RQ increased
- ≈4%
- High-carbohydrate overfeeding: 24-h RQ increased
- ≈9%
- On average
Original publication
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