The association between Apolipoprotein A1 , Apolipoprotein B and their ratio with diabetes‐related neuropathy in elderly patients
Authors' conclusion
Elevated ApoB and ApoB/A1 ratio are significantly associated with diabetes-related neuropathy in elderly T2DM patients. The ApoB/A1 ratio may serve as a valuable biomarker for identifying individuals at higher risk of neuropathic complications.
Study context
- Population
- T2D patients aged ≥60 years
- Participants
- 63 patients
- Exposure
- Neuropathy vs no neuropathy
- Outcome
- Association of ApoA1, ApoB and ApoB/A1 ratio with diabetes-related neuropathy by MNSI scores
Main finding
As reported in the abstract
Neuropathy prevalence
55.6%
Correlation Michigan Neuropathy Screening Instrument (MNSI) score with Apolipoprotein B (ApoB) (r)
r = 0.426
p < 0.001
Correlation MNSI score with ApoB/A1 ratio (r)
r = 0.431
p < 0.001
Observational data: associations, not effects.
Further findings
HbA1c correlations with apolipoproteins
- HbA1c positively correlated with ApoB and ApoB/A1 ratio, negatively with Apolipoprotein A1 (ApoA1)
Original publication
The association between Apolipoprotein A1 , Apolipoprotein B and their ratio with diabetes‐related neuropathy in elderly patients. Diabet Med. Published 23 January 2026. doi:10.
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