The 24-Hour Urinary Cortisol/Urinary Creatinine Ratio Helps Differentiate Cushing's Syndrome From Simple Obesity
Main finding · CS per increase in 24hUCor/CrResult — go to the resultOdds ratio 2.05 95% CI 1.56–2.71Authors' conclusion
A higher 24hUCor/Cr helped to identify CS with an optimal cutoff value of 52.3554.
Study context
- Population
- Hospitalized patients evaluated for cushing's syndrome (CS) vs simple obesityhospitalized
- Participants
- 395 patients
- Exposure
- 24-hour urinary cortisol/urinary creatinine ratio for identifying CS
- Outcome
- Association of 24hUCor/Cr with CS
Main finding
CS per increase in 24hUCor/Cr
Odds ratio
2.05
95% CI 1.56–2.71
P < 0.001
24hUCor/Cr (unadjusted)
OR 2.05 (95% CI 1.56–2.71); P < 0.001
Per increase in 24hUCor/Cr, as printed
As reported in the abstract
- Fully adjusted model: risk of CS increased by 74% per SD increase in 24hUCor/Cr
- 74% (95% CI 1.02-2.97; P < .05)
- Diagnosed with CS
- 94 (23.8%)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Diagnostic performance of 24hUCor/Cr for CS (ROC, Youden's index)All subjects | 24hUCor/Cr sensitivity 88.3% · specificity 91.7% · cutoff 52.3554 · AUC 0.942 |
- Diagnostic performance of 24hUCor/Cr for CS (ROC, Youden's index): P < .001
Original publication
The 24-Hour Urinary Cortisol/Urinary Creatinine Ratio Helps Differentiate Cushing's Syndrome From Simple Obesity. Endocr Pract. Published 6 November 2024. doi:10.
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