Testing for associations between HbA1c levels, polygenic risk and brain health in UK Biobank ( N = 39 283)
Authors' conclusion
Our findings suggest that measured HbA1c is associated with poorer cognitive health, and that HbA1c-PRS do not add significant information to this.
Study context
- Population
- UK Biobank participants with cognitive test scores and brain imaging phenotypes
- Participants
- 39,283 participants
- Exposure
- Higher vs lower continuous HbA1c levels and HbA1c-polygenic risk scores (HbA1c-PRS)
- Outcome
- Cognitive test scores and brain imaging phenotypes
Methodological detailsUK Biobank data, adjusted for confounders
- UK Biobank data
- Adjusted for confounders
Main finding
As reported in the abstract
Higher HbA1c and symbol digit substitution scores (standardized β), fully adjusted, P = .001
−0.022
Higher HbA1c and grey matter (GM) volume (β), fully adjusted, P < .001
−0.026
Higher HbA1c and whole brain volume (β), P = .0113
−0.072
Higher HbA1c and general factor of frontal lobe GM (β), P < .001
−0.022
Observational data: associations, not effects.
Further findings
- HbA1c-PRS and GM volume (β), fully adjusted, P = .0113
- −0.010
- When adjusted for HbA1c levels, the association was not significant
Original publication
Testing for associations between HbA1c levels, polygenic risk and brain health in UK Biobank ( N = 39 283). Diabetes Obes Metab. Published 12 July 2023. doi:10.
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