Synergistic association of estradiol and body roundness index with accelerated biological aging in male individuals
Authors' conclusion
Both serum estradiol and BRI are significantly associated with accelerated biological aging in male individuals. Integrating high estradiol with high BRI might noticeably reinforce this association.
Study context
- Population
- Male individuals aged 20 to 79 years, NHANES 2015–2016
- Participants
- 1,818 individuals
- Exposure
- Serum estradiol and body roundness index (BRI), independently and jointly, in relation to accelerated biological aging
- Outcome
- Accelerated biological aging (positive phenotypic age acceleration value)
Methodological detailsNHANES 2015-2016, weighted multivariate logistic regression, restricted cubic spline models
- NHANES 2015-2016
- Weighted multivariate logistic regression
- Restricted cubic spline models
Main finding
As reported in the abstract
Accelerated biological aging
- Independent association of serum estradiol and of BRI with accelerated biological aging, significant after covariate adjustment
- Association nonlinear for BRI; no similar nonlinear correlation for estradiol
- Coexistence of high serum estradiol and high BRI strengthened the association in adjusted models
Observational data: associations, not effects.
Original publication
Synergistic association of estradiol and body roundness index with accelerated biological aging in male individuals. Obesity (Silver Spring). Published 16 July 2025. doi:10.
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