Obesity

Adiposity associations with risk of colorectal cancer: a systematic review

Obesity (Silver Spring)Published Systematic review

Authors' conclusion

Standardization is needed to better elucidate the relation between CRC and adiposity to allow for comparisons across papers. Additionally, a balance among precision, accessibility, and cost of measurements must be struck.

Study context

Population
Adults aged older than 18 years with adiposity measures and incident colorectal cancer (CRC), colon or rectal cancer data15 articles · 10 studies
Comparison
Higher vs lower adiposity
Outcome
Incident colorectal cancer (CRC) risk
Methodological detailsSearched MEDLINE, Scopus, Embase, CINAHL and CENTRAL, Bias assessed with National Institutes of Health study quality assessment tools, Body composition measured by bioelectrical impedance, CT, DXA and US; most used total body fat mass, percent fat, abdominal visceral and subcutaneous adipose tissues
  • Searched MEDLINE, Scopus, Embase, CINAHL and CENTRAL
  • Bias assessed with National Institutes of Health study quality assessment tools
  • Body composition measured by bioelectrical impedance, CT, DXA and US; most used total body fat mass, percent fat, abdominal visceral and subcutaneous adipose tissues

Pooled result

As reported in the abstract

Significant positive associations

3

Significant negative association

1

Nonsignificant positive associations

11

Original publication

Adiposity associations with risk of colorectal cancer: a systematic review. Obesity (Silver Spring). Published 13 July 2025. doi:10.1002/oby.24314

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