Adiposity associations with risk of colorectal cancer: a systematic review
Authors' conclusion
Standardization is needed to better elucidate the relation between CRC and adiposity to allow for comparisons across papers. Additionally, a balance among precision, accessibility, and cost of measurements must be struck.
Study context
- Population
- Adults aged older than 18 years with adiposity measures and incident colorectal cancer (CRC), colon or rectal cancer data15 articles · 10 studies
- Comparison
- Higher vs lower adiposity
- Outcome
- Incident colorectal cancer (CRC) risk
Methodological detailsSearched MEDLINE, Scopus, Embase, CINAHL and CENTRAL, Bias assessed with National Institutes of Health study quality assessment tools, Body composition measured by bioelectrical impedance, CT, DXA and US; most used total body fat mass, percent fat, abdominal visceral and subcutaneous adipose tissues
- Searched MEDLINE, Scopus, Embase, CINAHL and CENTRAL
- Bias assessed with National Institutes of Health study quality assessment tools
- Body composition measured by bioelectrical impedance, CT, DXA and US; most used total body fat mass, percent fat, abdominal visceral and subcutaneous adipose tissues
Pooled result
As reported in the abstract
Significant positive associations
3
Significant negative association
1
Nonsignificant positive associations
11
Original publication
Adiposity associations with risk of colorectal cancer: a systematic review. Obesity (Silver Spring). Published 13 July 2025. doi:10. 1002/ oby. 24314
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