Switching from treatment with sensor augmented pump to hybrid closed loop system in type 1 diabetes: Impact on glycemic control and neuropsychological tests in the real world
Authors' conclusion
Switching from SAP to HCL system improves time in range and reduces time in hypoglycemia and glycemic variability at 3 months. These changes are accompanied by significant reduction of neuropsychological burden related to diabetes.
Study context
- Population
- Patients with T1D using sensor-augmented pump (SAP) switching to hybrid closed loop (HCL) in a specialized hospital; 74% women, mean age 44 ± 11 years, diabetes duration 27.2 ± 11 years
- Participants
- 66 consecutive patients
- Exposure
- HCL after switching vs SAP at baseline
- Outcome
- Glycemic control (glucometric data) and quality of life
- Follow-up
- 3 months
Methodological detailsreal-world, single-centre, before-after
- Real-world
- Single-centre
- Before-after
Main finding
As reported in the abstract
Glucometric data
- CV, SAP to HCL (significant improvement)
- from 35.6% to 33.1%
- TIR, SAP to HCL (significant improvement)
- from 62.2 % to 73.8%
- Time above 180 mg/dl, SAP to HCL (significant improvement)
- from 26.9% to 18%
- Time below 70 mg/dl, SAP to HCL (significant improvement)
- from 3.3% to 2.1%
- Time below 55 mg/dl, SAP to HCL (significant improvement)
- from 0.7% to 0.3%
Observational data: associations, not effects.
Further findings
Neuropsychological tests · 3 months
- Significant improvements in fear of hypoglycemia and grade of distress associated to treatment and to interpersonal sphere
Original publication
Switching from treatment with sensor augmented pump to hybrid closed loop system in type 1 diabetes: Impact on glycemic control and neuropsychological tests in the real world. Diabetes Res Clin Pract. Published 24 May 2023. doi:10.
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