Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes
Authors' conclusion
Participants in C5 had the highest benefit from bariatric surgery in terms of improvement in insulin resistance, β-cell function, and prediabetes remission. This novel classification might help identify individuals who will benefit specifically from bariatric surgery.
Study context
- Population
- Individuals without T2D but at risk for T2D (elevated BMI), with normal glucose regulation or prediabetes (ADA criteria), undergoing bariatric surgery; discovery cohort Lille, France; replication cohort Rome, Italy; control cohort Tübingen, Germany
- Participants
- 121 / 180 / 503
- Exposure
- Bariatric surgery outcomes across Tübingen Clusters C4, C5 and C6
- C4n = 121
- C5n = 180
- C6n = 503
- Outcome
- Alteration of glucose regulation parameters and prediabetes remission
Methodological detailsdiscovery and replication cohorts, control cohort with behavioral modification counseling
- Discovery and replication cohorts
- Control cohort with behavioral modification counseling
Main finding
As reported in the abstract
- Relative body weight loss similar among all clusters
- Reduction of insulin resistance and improvement of β-cell function strongest in C5
- Prediabetes remission rate lowest in low-risk C4 and highest in high-risk C5
Observational data: associations, not effects.
Further findings
Cluster change
- Individuals from high-risk clusters changed to low-risk clusters in both bariatric surgery cohorts but not in the control cohort
Original publication
Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes. Diabetes Care. Published 11 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →