Overweight/obesity and gastrointestinal disease incidence in Denmark—a cohort study
Main finding · Any GI diseaseResult — go to the resultAdjusted hazard ratio 1.7 95% CI 1.7–1.7Authors' conclusion
Overweight/obesity is a risk factor for a wide range of GI diseases and is expected to become an even greater clinical challenge in the future.
Study context
- Population
- All Danes ≥18 years with a hospital diagnosis of overweight/obesity, Denmark 1997–2018; 70.9% female, median age 49.3 yearsmatched cohort
- Exposure
- Overweight/obesity vs matched general population comparators
- Overweight/obesityn = 129,466
- Outcome
- Incidence of hospital-diagnosed GI diseases
- Follow-up
- From 1 year after overweight/obesity diagnosis
Methodological detailsnationwide healthcare registries, age- and sex-matched general population comparison cohort
- Nationwide healthcare registries
- Age- and sex-matched general population comparison cohort
Main finding
Any GI disease
Adjusted hazard ratio
1.7
95% CI 1.7–1.7
By group
Overweight/obesity
30.1 per 1000 person years
CI 29.8–30.5
Comparators
16.7
CI 16.5–16.8
Overweight/obesityvs Comparators
aHR 1.7 (95% CI 1.7–1.7)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Gastrointestinal (GI) disease sub-types (aHR, overweight/obesity cohort vs comparators)
- Cholelithiasis aHR
- 2.8 (95% CI 2.7-2.9)
- Cholecystitis aHR
- 2.6 (95% CI 2.4-2.8)
- Acute pancreatitis aHR
- 2.2 (95% CI 2.0-2.4)
- Stomach ulcer aHR
- 2.0 (95% CI 1.9-2.1)
- Cirrhosis aHR
- 1.5 (95% CI 1.3-1.7)
- Obesity-associated GI cancer aHR
- 1.2 (95% CI 1.2-1.3)
- Elevated risk of all GI disease sub-types
Any GI disease, by sex
- Men aHR
- 1.4 (95% CI 1.4-1.5)
- Women aHR
- 1.9 (95% CI 1.8-1.9)
Any GI disease, by age
- Age 18 to <30 years aHR
- 2.6 (95% CI 2.5-2.7)
- Age ≥70 years aHR
- 1.3 (95% CI 1.3-1.4)
Original publication
Overweight/obesity and gastrointestinal disease incidence in Denmark—a cohort study. Eur J Endocrinol. Published 10 April 2025. doi:10.
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