Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
Authors' conclusion
Our data show that s.c. tirzepatide had a more pronounced effect on HbA1c and weight reduction compared with s.c. semaglutide in people with type 2 diabetes. Both drugs, particularly higher doses of tirzepatide, increased gastrointestinal adverse events.
Study context
- Population
- Adults with T2D, any background glucose-lowering treatment; RCTs ≥12 weeks (PubMed and Cochrane to 11 November 2023); 44.2% female
- Participants
- 23,622 adults28 trials
- Comparison
- s.c. tirzepatide vs s.c. semaglutide
- Outcome
- Change in HbA1c and body weight from baseline
Methodological detailsfrequentist random-effects network meta-analysis, ROB 2 risk-of-bias assessment, Confidence In Network Meta-Analysis (CINeMA) confidence assessment
- Frequentist random-effects network meta-analysis
- ROB 2 risk-of-bias assessment
- CINeMA confidence assessment
Pooled result
As reported in the abstract
Change in HbA1c vs placebo
Mean difference, mmol/mol
- Tirzepatide 15 mg · −1.96%
- −21.61
- Tirzepatide 10 mg · −1.84%
- −20.19
- Semaglutide 2.0 mg · −1.59%
- −17.74
- Tirzepatide 5 mg · −1.60%
- −17.60
- Semaglutide 1.0 mg · −1.39%
- −15.25
- Semaglutide 0.5 mg · −1.09%
- −12.00
kg
- Body weight reduction vs placebo, tirzepatide 15 mg
- 9.57
- Body weight reduction vs placebo, tirzepatide 5 mg
- 5.27
- Body weight reduction vs placebo, semaglutide 2.0 mg
- 4.97
- Body weight reduction vs placebo, semaglutide 0.5 mg
- 2.52
Safety
- Both drugs increased incidence of gastrointestinal adverse events vs placebo
- Neither tirzepatide nor semaglutide increased risk of serious adverse events or severe hypoglycaemia
Original publication
Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials. Diabetologia. Published 13 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →