Spectrum of Adrenal Dysfunction in Hemoglobin E/Beta Thalassemia
Authors' conclusion
Adrenal insufficiency is common in HbE/beta thalassemia and is independent of transfusion dependency and disease severity.
Study context
- Population
- Patients with hemoglobin E (HbE)/beta thalassemia; morning cortisol, ACTH, aldosterone, renin; 1 μg and 250 μg short Synacthen test if baseline cortisol 5 to 18 μg/dL
- Participants
- 104 patients
- Exposure
- Transfusion dependent vs non-transfusion dependent; mild vs moderate vs severe disease
- Transfusion dependentn = 57
- Non-transfusion dependentn = 47
- Mildn = 39
- Moderaten = 39
- Severen = 26
- Outcome
- Prevalence of AI
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Adrenal insufficiency (AI)
41%
n = 43
Primary AI, among those with AI
83.7%
n = 34
Secondary AI, among those with AI
16.3%
n = 9
Subclinical AI
33
31%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Prevalence of AI by transfusion dependencyBetween Transfusion dependent and Non-transfusion dependent · no difference | P = 0.56 |
Prevalence of AI by disease severity
- No difference in prevalence of AI according to disease severity
- P = 0.52
Original publication
Spectrum of Adrenal Dysfunction in Hemoglobin E/Beta Thalassemia. J Clin Endocrinol Metab. Published 29 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →