Adrenocorticotropic Hormone Measured by Immulite 1000 and Elecsys Assay Platforms in Suspected Cases of Hypocortisolism: A Word of Caution
Authors' conclusion
Use of Immulite 1000 platform may result in falsely elevated ACTH values. Physicians should exercise caution while interpreting the results and repeat test using a different assay platform may be considered.
Study context
- Population
- Patients with haemoglobin E/beta-thalassemia assessed for hypocortisolism; 34 primary, 9 secondary, 33 subclinical adrenal insufficiency (1 μg and 250 μg Synacthen tests)
- Participants
- 104 patients
- Exposure
- Adrenocorticotropic Hormone (ACTH) measured by Immulite 1000 vs Elecsys Cobas
- Outcome
- Plasma ACTH
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
P < 0.001
- Correlation between platforms (r)
- 0.341, P < .001
- Agreement between platforms (Cohen's κ), not strong
- 0.208, P = .001
Observational data: associations, not effects.
Further findings
Diagnosis of primary adrenal insufficiency
Specificity
Secondary adrenal insufficiency with inappropriately elevated ACTH on Immulite 1000
- Patients with secondary adrenal insufficiency with inappropriately elevated ACTH (Immulite 1000)
- 2
Original publication
Adrenocorticotropic Hormone Measured by Immulite 1000 and Elecsys Assay Platforms in Suspected Cases of Hypocortisolism: A Word of Caution. Endocr Pract. Published 4 March 2025. doi:10.
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