Smart Pen Exposes Missed Basal Insulin Injections and Reveals the Impact on Glycemic Control in Adults With Type 1 Diabetes
Authors' conclusion
This is the first study, based on accurate real-world injection data, to demonstrate the challenge of adherence to basal insulin injections in patients with T1D, and document that just one missed basal injection per week can result in clinically significant changes in glycemic control.
Study context
- Population
- Adults with T1D using continuous glucose monitoring (CGM), given a smart insulin pen (NovoPen 6), Sweden4,410 CGM days
- Participants
- 32 adults
Primary result
As reported in the abstract
Probability of missing ≥1 basal insulin dose (≥40 h between doses) over any 14-day period
Estimated probability of missing ≥1 basal dose per 14-day period
22%
95% CI 10%–40%
Missed basal doses per 14-day period (315 periods), range
0 to 4
Further findings
Association of missed basal doses with glycaemic outcomes
- Missed basal doses significantly associated with higher mean glucose, higher GMI and lower TIR (70-180 mg/dL)
- Similar results when adjusted for missed bolus doses; age and sex had no significant effect on any glycaemic parameter
Original publication
Smart Pen Exposes Missed Basal Insulin Injections and Reveals the Impact on Glycemic Control in Adults With Type 1 Diabetes. J Diabetes Sci Technol. Published 1 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →