Simplified Meal Bolus Strategies with Control-IQ+ Automated Insulin Delivery Are Safe and Effective in Adults with Type 2 Diabetes
Authors' conclusion
Simplified bolus strategies worked well for adults with type 2 diabetes using Control-IQ+ in the 2IQP trial. All bolus strategies led to substantial HbA1c improvements, without safety concerns.
Study context
- Population
- Adults with insulin-treated T2D using Control-IQ+ automated insulin delivery (AID) in the AID arm of the 2IQP trialAID arm
- Participants
- 201 adults
- Comparison
- Meal bolus strategies with Control-IQ+ AID vs baseline
- Carbohydrate Countingn = 68
- Preset Carbohydrate Amountsn = 79
- Fixed Insulin Dosesn = 27
- Other Methodsn = 27
Methodological details13-week
- 13-week
Primary result
As reported in the abstract
Change in HbA1c from baseline
| Group | Value | P |
|---|---|---|
| Carbohydrate Counting | −0.9% | P < 0.001 |
| Preset Carbohydrate Amounts | −1.1% | P < 0.001 |
| Fixed Insulin Doses | −0.8% | P < 0.001 |
| Other Methods | −0.9% | P = 0.003 |
Value
Carbohydrate Counting−0.9%
Preset Carbohydrate Amounts−1.1%
Fixed Insulin Doses−0.8%
Other Methods−0.9%
P
Carbohydrate CountingP < 0.001
Preset Carbohydrate AmountsP < 0.001
Fixed Insulin DosesP < 0.001
Other MethodsP = 0.003
Further findings
Use of a simplified bolus strategy · second vs first half of study
- Participants using a simplified bolus strategy, second half vs first half
- 63% vs. 52%
Safety
- Hypoglycemia rates low at baseline and remained low for all bolus strategies
Original publication
Simplified Meal Bolus Strategies with Control-IQ+ Automated Insulin Delivery Are Safe and Effective in Adults with Type 2 Diabetes. Diabetes Technol Ther. Published 14 November 2025. doi:10.
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