Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes
Authors' conclusion
Our data suggest the existence of a gut-bone axis reducing bone resorption in response to oral glucose independently of plasma glucose excursions and insulin secretion. Subjects with type 1 diabetes showed impaired suppression of bone resorption and reduced bone formation during OGTT, which may allude to the reduced bone mineral density and increased fracture risk characterizing these individuals.
Study context
- Population
- Individuals with C-peptide negative T1D and healthy controls, Center for Clinical Metabolic Research, Gentofte Hospital, Denmark
- Participants
- 9 vs 8
- Comparison
- Oral glucose tolerance test (OGTT) vs isoglycemic IV glucose infusion in T1D and healthy controls
- T1Dn = 9
- Healthy controlsn = 8reference
- Outcome
- Changes in bone resorption (CTX) and bone formation (PINP) during OGTT and IIGI
Methodological detailsobservational, matched for gender, age and BMI
- Observational
- Matched for gender, age and BMI
Main finding
As reported in the abstract
- Baseline CTX and PINP similar in the 2 groups
- Both groups: significantly greater CTX suppression during OGTT than isoglycemic intravenous glucose infusion (IIGI)
- Healthy controls: PINP unaffected by OGTT and IIGI
- T1D: impaired CTX suppression and inappropriate PINP suppression during OGTT
Observational data: associations, not effects.
Original publication
Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes. J Clin Endocrinol Metab. Published 19 July 2023. doi:10.
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