Sex Differences in Cardiovascular Disease and Cardiovascular Risk Estimation in Patients With Type 1 Diabetes
Authors' conclusion
Both men and women with T1D are at high CVD risk. The 10-year estimated CVD risk was higher in men aged <55 years than in women of similar age, but these sex differences disappeared at age ≥55 years, suggesting that female sex was no longer protective.
Study context
- Population
- Adults with T1D (mean age 46 years; 44.9% women)
- Participants
- 2,041 adults
- Exposure
- Men vs women
- Outcome
- Sex-related differences in CVD prevalence and 10-year estimated CVD risk (Steno type 1 risk engine, in patients without pre-existing CVD)
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
CVD prevalence (n = 116)
Mean 10-year estimated cardiovascular disease (CVD) risk without pre-existing CVD (n = 1925), no significant sex difference
15.4 ± 0.4%
Observational data: associations, not effects.
Further findings
Carotid artery plaque burden
- Associated with age ≥55 years and with medium and high 10-year estimated CVD risk, without significant sex difference
Diabetic retinopathy and sensory-motor neuropathy
- Associated with higher 10-year CVD risk and female sex
Original publication
Sex Differences in Cardiovascular Disease and Cardiovascular Risk Estimation in Patients With Type 1 Diabetes. J Clin Endocrinol Metab. Published 7 March 2023. doi:10.
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