Sex‐ and Age‐Specific Metabolic Outcomes of Prolactin Normalisation in Hyperprolactinaemia
Authors' conclusion
PRL normalisation with cabergoline was associated with modest improvements in conventional lipid fractions and a more consistent reduction in the TyG index, suggesting a preferential impact on insulin-resistance-related pathways. The absence of independent effects of sex, age, PRL dynamics, or cabergoline exposure on lipid changes underscores the need for cautious interpretation of statistically significant but small absolute shifts.
Study context
- Population
- Patients with hyperprolactinaemia treated with cabergoline with paired clinical and biochemical measurements before and after prolactin (PRL) normalisation (286 women, 159 men)286 women · 159 men
- Participants
- 445 patients
- Exposure
- Before vs after PRL normalisation with cabergoline
- Outcome
- Metabolic parameters after PRL normalisation
Methodological detailspre-post analysis, stratified by sex and age, multivariable models
- Pre-post analysis
- Stratified by sex and age
- Multivariable models
Main finding
As reported in the abstract
Total cholesterol reduced (mg/dL), p < 0.001
185 → 181
LDL-C reduced (mg/dL), p = 0.038
110 → 106
TG reduced (mg/dL), p < 0.001
91 → 82
Observational data: associations, not effects.
Further findings
Baseline characteristics by sex
- Men had more severe baseline disease: higher PRL, more macroadenomas, hypopituitarism and cardiometabolic comorbidities
Multivariable predictors
- Lipid changes not independently explained by sex, age, PRL dynamics, cabergoline exposure or gonadal status
- Higher initial cabergoline dose and baseline hypogonadism independently determined greater TyG reduction
Original publication
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