Severity of MASH activity by iron-corrected MRI predicts insulin resistance and cardiometabolic risk in type 2 diabetes
Authors' conclusion
In people with T2D, worse MASH disease activity (measured by cT1) is associated with unfavorable cardiometabolic risk factors that are known to drive liver disease progression. Use of cT1 in this population may help early identification of at-risk individuals who would benefit from earlier aggressive intervention in primary care.
Study context
- Population
- Participants with T2D from primary care settings
- Participants
- 109 participants
- Exposure
- Four groups by cT1 and liver fat content
- Outcome
- Association of MASH disease activity (cT1) with cardiometabolic risk factors
Methodological detailsprimary care settings
- Primary care settings
Main finding
As reported in the abstract
- Higher cT1 associated with more severe features of the metabolic syndrome, increased insulin resistance (HOMA-IR) and adipose tissue dysfunction (higher Adipo-IR, decreased adiponectin)
- all P < .01
- Elevated cT1 correlated with worse hepatic necroinflammation (FAST, NIS2+®, CK-18) and more severe steatosis and fibrosis
- all P < .001
Observational data: associations, not effects.
Original publication
Severity of MASH activity by iron-corrected MRI predicts insulin resistance and cardiometabolic risk in type 2 diabetes. J Clin Endocrinol Metab. Published 11 February 2026. doi:10.
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