Lipids & metabolic liver disease
Serum IGF ‐1 and the Risk of Cardio‐Kidney Outcomes in Metabolic Dysfunction‐Associated Steatotic Liver Disease
An erratum to this article was published (Diabetes Obes Metab, Oct 2026 ↗)
Main finding · Composite CKOResult — go to the resultAdjusted hazard ratio 1.24 95% CI 1.18–1.30Authors' conclusion
MASLD independently predicted CKO, particularly among individuals with low IGF-1 levels.
Study context
- Population
- UK Biobank participants without baseline cardiovascular disease or CKDUK Biobank
- Participants
- 214,512 participants
- Exposure
- MASLD stratified by age- and sex-specific IGF-1 tertiles vs no-MASLD
- Outcome
- Composite cardio-kidney outcome (CKO)
- Follow-up
- median 13-year follow-up
Methodological detailsUK Biobank, multivariable Cox models
- UK Biobank
- Multivariable Cox models
Main finding
Composite CKO
Adjusted hazard ratio
1.24
95% CI 1.18–1.30
MASLD T1vs no-MASLD
aHR 1.24 (95% CI 1.18–1.30)
As reported in the abstract
- Cardio-kidney outcomes (CKOs) occurred
- 20 395
- MASLD increased event rates across all IGF-1 tertiles
- P < 0.001
- Significant interaction between MASLD and IGF-1 levels
- P for interaction = 0.014
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident CKD · median 13-year follow-upT1vs no-MASLDSimilar trend to CKO, MASLD in lowest IGF-1 tertile · multivariable Cox models | 1.35 (1.22–1.49) | |
| 3P-MACE · median 13-year follow-upT1vs no-MASLDSimilar trend to CKO, MASLD in lowest IGF-1 tertile · multivariable Cox models | 1.26 (1.18–1.35) | |
| 0.512Adjusted hazard ratio (log scale) |
Subgroups: sex, BMI, DM, age, albuminuria
- Consistent associations across sex, BMI and DM; stronger effects in participants <65 years; markedly greater CKD risk with baseline albuminuria
Original publication
Serum IGF ‐1 and the Risk of Cardio‐Kidney Outcomes in Metabolic Dysfunction‐Associated Steatotic Liver Disease. Diabetes Obes Metab. Published 27 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →