Serum Concentrations of Inhibin B in Healthy Females and Males Throughout Life
Authors' conclusion
Valuable sex- and age-specific reference data for inhibin B concentrations were provided. In OC users, decreased concentrations of inhibin B underlined the ovaries as the only place of inhibin B production. In patients with Klinefelter syndrome, the decline in inhibin B concentrations at puberty underlined the shift in regulation of inhibin B production at pubertal onset.
Study context
- Population
- Healthy females and males aged 0 to 80 years; also patients with Klinefelter syndrome
- Participants
- 2,707 healthy controls
- Outcome
- Sex- and age-specific reference ranges of serum inhibin B according to pubertal development
Methodological detailsreference range construction
- Reference range construction
Main finding
As reported in the abstract
Inhibin B throughout life
- In both sexes, inhibin B high during minipuberty, decreased in childhood, increased from Tanner B1 to B3 (peak B4) in females and G1 to G3 (peak G3) in males
- Females: relatively constant after puberty (variations in menstruating females) until unmeasurable at menopause
- Males: relatively high from puberty onward despite a modest decrease
- At any age, males had highest concentrations
Observational data: associations, not effects.
Further findings
| Outcome | OC users | Nonusers | P value |
|---|---|---|---|
| Inhibin B SD scores by oral contraceptive useLower in OC users | median −0.88 SD score | 0.35 SD score | P < 0.001 |
Inhibin B in Klinefelter syndrome (n=42)
- Spanned the reference range until ≈15 years of age, then decreased to subnormal or unmeasurable levels
Original publication
Serum Concentrations of Inhibin B in Healthy Females and Males Throughout Life. J Clin Endocrinol Metab. Published 26 June 2024. doi:10.
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