Second Primary Cancer Among Patients With Papillary Thyroid Carcinoma Following the Chernobyl Disaster
Authors' conclusion
This cohort study reports the increased incidence of solid secondary tumors in men and women over a 31-year time frame after the Chernobyl disaster. Moreover, there was a statistically significant increased risk of second tumors of the breast, colon, rectum, mesothelium, eye, adnexa, meninges, and adrenal glands as well as Kaposi sarcoma. These data might have an effect on the follow-up of this cohort of patients to detect secondary malignant tumors at an early stage.
Study context
- Population
- Patients with primary papillary thyroid carcinoma (PTC) in the Republic of Belarus after the Chernobyl disaster, Belarussian Cancer Registry, observed 1990–2021
- Participants
- 30,568 patients
- Outcome
- Incidence of second primary malignant tumor (synchronous and metachronous) after PTC, as standardized incidence ratios
- Follow-up
- January 1, 1990, to December 31, 2021
Methodological detailspopulation-based, cancer registry
- Population-based
- Cancer registry
Main finding
As reported in the abstract
- Developed a second malignant tumor
- 2820 (9.2%)
- Women / men with second malignant tumor
- 2204 / 616
- Standardized incidence ratio, all types of cancer
- 1.25 (95% CI 1.21-1.30)
- Standardized incidence ratio, solid malignant tumors
- 1.20 (95% CI 1.15-1.25)
- Standardized incidence ratio, all leukemias
- 1.61 (95% CI 2.17-2.13, as printed)
Observational data: associations, not effects.
Further findings
Most prevalent second primary tumors in women
- Digestive system
- 466 cases [21.1%]
- Genital organs
- 376 cases [17.1%]
- Breasts
- 603 cases [27.4%]
Most prevalent second primary tumors in men
- Gastrointestinal tract
- 146 cases [27.7%]
- Genitourinary system
- 139 cases [22.6%]
- Urinary tract
- 139 cases [22.6%]
Most prevalent second primary tumors overall
- Urinary tract cancers
- 307 cases [10.9%]
- Gastrointestinal tumors
- 612 cases [21.4%]
Age
- Mean (SD) age at primary cancer, years
- 53.9 (12.6)
- Mean (SD) age at secondary cancer, years
- 61.5 (11.8)
Original publication
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