Safety of User-Initiated Intensification of Insulin Delivery Using Cambridge Hybrid Closed-Loop Algorithm
Authors' conclusion
Use of an algorithm intensification mode in HCL therapy is safe across all age groups with type 1 diabetes. The higher time in hyperglycemia observed on "Boost" days suggests that users are more likely to use algorithm intensification on days with extreme hyperglycemic excursions.
Study context
- Population
- People with T1D using the Cambridge hybrid closed-loop (HCL) system: young children (1–7 years, n = 24), children and adolescents (10–17 years, n = 19), adults (≥24 years, n = 13), older adults (≥60 years, n = 20); participants with <10 Boost days excluded8 weeks of data
- Participants
- 76 people
- Exposure
- Days with ≥30 min of Boost use vs days with no Boost use
- Outcome
- Time spent in hypoglycemia <70 and <54 mg/dL
Methodological detailswithin-participant comparison of Boost days vs non-Boost days
- Within-participant comparison of Boost days vs non-Boost days
Main finding
As reported in the abstract
Time in hypoglycemia <70 and <54 mg/dL
Each group vs non-Boost daysMean difference, time <70 mg/dL, % (95% CI)P value
Boost days
−0.10(−0.28 to 0.07)
P = 0.249Each group vs non-Boost daysMean difference, time <54 mg/dL (95% CI)P value
Boost days
0.03(−0.04 to 0.09)
P = 0.416Observational data: associations, not effects.
Further findings
| Outcome | Difference (percentage points) (CI) | P value | |
|---|---|---|---|
| Time in significant hyperglycemia >300 mg/dLHigher on Boost days | 1.39 (1.01–1.77) | P < 0.001 | |
| −1012Difference, percentage points (linear scale) |
| Outcome | P value |
|---|---|
| Mean glucose and TIRHigher mean glucose and lower TIR on Boost days | P < 0.001 |
Original publication
Safety of User-Initiated Intensification of Insulin Delivery Using Cambridge Hybrid Closed-Loop Algorithm. J Diabetes Sci Technol. Published 8 December 2022. doi:10.
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