Role of the liver in the sustained normalisation of A1c over 2 years following short‐term insulin therapy in early type 2 diabetes
Authors' conclusion
While lower baseline A1c and greater reduction in central adiposity predicted A1c <6.0% at 2 years as anticipated, the emergence of greater reduction in ALT as a concomitant determinant highlights the role of the liver in the achievement of sustained glycaemic normalisation.
Study context
- Population
- Adults with early T2D (mean duration 1.7 ± 1.4 years) given 3 weeks of induction intensive insulin therapy (IIT) (glargine, lispro), then metformin maintenance with or without periodic 2-week IIT courses every 3 months for 2 years
- Participants
- 101 adults
- Comparison
- A1c <6.0% at 2 years vs not, after induction IIT and metformin maintenance
- A1c <6.0%n = 26
- Primary endpoint
- Determinants of sustained normalisation of A1c (A1c <6.0%)
- Follow-up
- 2 years
Primary result
As reported in the abstract
Independent predictors of A1c <6.0% at 2 years (logistic regression)
Baseline A1c, aOR (95% CI 0.001-0.16), p = 0.001
0.01
Change in waist circumference from 3 weeks to 2 years, aOR (0.63-0.94), p = 0.012
0.77
Change in ALT from 3 weeks to 2 years, aOR (0.82-0.98), p = 0.019
0.90
Further findings
| Outcome | P value |
|---|---|
| Changes during maintenance therapy · 3 weeks to 2 yearsA1c <6.0% vs Other | P = 0.02 |
| Changes during maintenance therapy · 3 weeks to 2 yearsA1c <6.0% vs Other | P = 0.02 |
| Changes during maintenance therapy · 3 weeks to 2 yearsA1c <6.0% vs Other | P = 0.02 |
| Changes during maintenance therapy · 3 weeks to 2 yearsA1c <6.0% vs Other | P = 0.005 |
Baseline characteristics
- Lower A1c and fasting glucose and better beta-cell function in A1c <6.0% vs other participants
Changes during maintenance therapy · 3 weeks to 2 years
- Relative stabilisation of beta-cell function and glycaemia in A1c <6.0%
Original publication
Role of the liver in the sustained normalisation of A1c over 2 years following short‐term insulin therapy in early type 2 diabetes. Diabetes Obes Metab. Published 28 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →