Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong
Main finding · Major osteoporotic fracturesResult — go to the resultHazard ratio 1.22 95% CI 1.15–1.31Authors' conclusion
Our study demonstrated increased risk of major osteoporotic fractures after SARS-CoV-2 infection in both acute and post-acute phases in older adults, partly due to increased fall risk.
Study context
- Population
- Individuals aged ≥50, Hong Kong Hospital Authority electronic database, January 2020 to March 20221:1 matched
- Exposure
- COVID-19 vs no COVID-19
- COVID-19n = 429,459
- Outcome
- Composite of major osteoporotic fractures (hip, clinical vertebral, and upper limb)
- Follow-up
- Median 11 months
Methodological detailspropensity-score matched, population-based, 1:1 matched
- Propensity-score matched
- Population-based
- 1:1 matched
Main finding
Major osteoporotic fractures
Hazard ratio
1.22
95% CI 1.15–1.31
By group
COVID-19
5.08 per 1000 persons
Non-COVID
3.95 per 1000 persons
COVID-19vs Non-COVID
HR 1.22 (95% CI 1.15–1.31)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | COVID-19 | Non-COVID | HR (CI) | |
|---|---|---|---|---|
| Hip fractures · median follow-up 11 months | 2.71 | 1.94 | 1.33 (1.22–1.46) | |
| Clinical vertebral fractures · median follow-up 11 months | 0.42 | 0.31 | 1.29 (1.03–1.62) | |
| Falls · median follow-up 11 months | 13.83 | 10.36 | 1.28 (1.23–1.33) | |
| 0.512Hazard ratio (log scale) |
Subgroup analyses
- Subgroup analyses revealed no significant interaction
Fractures and falls in acute (within 30 days) and post-acute (beyond 30 days) phases
- Consistently significant increase in fractures and falls risks in both phases
Original publication
Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong. J Bone Miner Res. Published 9 March 2024. doi:10.
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