Risk Factors, Microbiology, and Prognosis of Diabetic Foot Osteomyelitis: A Retrospective Cohort Study
Authors' conclusion
Higher Wagner grades were independent risk factors for DFO. Major amputation does not improve 5-year survival rates in DFO patients.
Study context
- Population
- Persons diagnosed with diabetic foot disease admitted to a grade-A tertiary hospital, January 2012 to December 2022
- Participants
- 456 persons
- Exposure
- Diabetic foot osteomyelitis (DFO) vs DF without osteomyelitis
- Outcome
- Independent risk factors for DFO (multifactorial Cox regression)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Independent risk factor for DFO: higher Wagner grade
Higher Wagner grades, HR
3.17
95% CI 2.04, 4.94
Observational data: associations, not effects.
Further findings
Microbiology of DFO (positive bone or deep tissue cultures)
- DFO patients with positive bone or deep tissue cultures
- 62
- Staphylococcus aureus
- 11.29%
- Enterococcus faecalis
- 11.29%
- Proteus vulgaris (most common Gram-negative)
- 4.84%
- Polymicrobial infections
- 27.41%
5-year survival
- 5-year survival lower in DFO patients than in matched DF controls
- 5-year survival lower with major amputation than minor amputation and nonamputation DFO patients
- Kaplan-Meier
Original publication
Risk Factors, Microbiology, and Prognosis of Diabetic Foot Osteomyelitis: A Retrospective Cohort Study. Endocr Pract. Published 29 January 2025. doi:10.
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