Risk factors for development of diabetic foot ulcer disease in two large contemporary UK cohorts
Authors' conclusion
Despite different methods of case ascertainment, multivariable analysis in both populations indicated that those who developed DFUD were more likely to be older, male, smokers, of White ethnicity, with higher systolic blood pressure and baseline HbA1c.
Study context
- Population
- People with diabetes in two large representative UK cohorts (England and Scotland)two cohorts
- Participants
- 131,042 vs 260,748
- Exposure
- CPRD vs SDRN-NDS
- CPRDn = 131,042
- SDRN-NDSn = 260,748
- Outcome
- Incidence of DFUD and its risk factors
Methodological detailstwo independent population cohorts, multivariable analysis
- Two independent population cohorts
- Multivariable analysis
Main finding
As reported in the abstract
Incident DFUD
Incident DFUD
Developed DFUD CPRD 4.7% · SDRN-NDS 2.9%
Median follow-up CPRD 4.3years · SDRN-NDS 6.3 years
Observational data: associations, not effects.
Original publication
Risk factors for development of diabetic foot ulcer disease in two large contemporary UK cohorts. Diabetes Obes Metab. Published 24 June 2025. doi:10.
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