Risk Factors for Bone Microarchitecture Impairments in Older Men With Type 2 Diabetes—The MrOS Study
Authors' conclusion
Older men with T2DM have smaller bone size compared to those without T2DM, which may contribute to diabetic skeletal fragility. Longer diabetes duration was associated with higher cortical porosity and insulin use with cortical bone deficits and lower failure load.
Study context
- Population
- Older men in the Osteoporotic Fractures in Men (MrOS) study with high-resolution peripheral quantitative computed tomography (HR-pQCT) scans1,794 scanned
- Participants
- 1,777 men
- Exposure
- T2DM vs non-T2DM
- T2DMn = 290
- Outcome
- HR-pQCT bone microarchitecture parameters by diabetes status
Methodological detailsmulticentre, linear regression adjusted for age, race, BMI, limb length, clinic site and oral corticosteroid use
- Multicentre
- Linear regression adjusted for age, race, BMI, limb length, clinic site and oral corticosteroid use
Main finding
As reported in the abstract
HR-pQCT parameters, T2DM vs non-T2DM
- Trabecular indices and cortical porosity were similar between T2DM and non-T2DM
- T2DM vs non-T2DM: P = 0.028
- T2DM vs non-T2DM: P = 0.025
- T2DM vs non-T2DM: P = 0.009
- T2DM vs non-T2DM: P = 0.023
Observational data: associations, not effects.
Further findings
Diabetes duration ≥10 vs <10 years (T2DM men; model incl. HbA1c, duration, insulin use)
- Significantly associated with higher cortical porosity but higher trabecular thickness at the distal radius
Insulin use (T2DM men)
- Significantly associated with lower cortical area and thickness at distal radius and diaphyseal tibia and lower failure load at all 3 scan sites
Incident nonvertebral fracture in T2DM
- Lower cortical area, cortical thickness, total BMD, cortical BMD and failure load of the distal sites associated with increased risk
Original publication
Risk Factors for Bone Microarchitecture Impairments in Older Men With Type 2 Diabetes—The MrOS Study. J Clin Endocrinol Metab. Published 12 July 2024. doi:10.
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