Resistance Exercise Counteracts the Impact of Androgen Deprivation Therapy on Muscle Characteristics in Cancer Patients
Authors' conclusion
The onset of ADT is followed by a decline in both type I and type II muscle fiber size and capillarization in PCa patients. Resistance exercise training offsets the negative impact of ADT and increases type I and II muscle fiber size and type I muscle fiber capillarization in these patients.
Study context
- Population
- Prostate cancer (PCa) patients (72 ± 6 years) starting androgen deprivation therapy (ADT)
- Participants
- 21 patients
- Comparison
- Resistance exercise training vs usual care during ADT
- Resistance exercise trainingn = 10
- Usual caren = 11reference
- Primary endpoint
- Muscle fiber characteristics (type I and II fiber distribution, fiber size, myonuclear and capillary contents) in vastus lateralis by immunohistochemistry
- Follow-up
- 20 weeks
Primary result
As reported in the abstract
Muscle fiber size (baseline to 20 weeks)
- Usual care: type I fiber size decreased, from 7401 ± 1183 to 6489 ± 1293 μm²
- P < .05
- Usual care: type II fiber size decreased, from 6225 ± 1503 to 5014 ± 714 μm²
- P < .05
- Resistance exercise training: type I fiber size increased, from 6700 ± 1464 to 7772 ± 1319 μm²
- P < .05
- Resistance exercise training: type II fiber size increased, from 5248 ± 892 to 6302 ± 1385 μm²
- P < .05
Further findings
Capillary-to-fiber ratio (C/Fi) · 20 weeks
- Usual care: type I C/Fi declined −12% ± 12%
- P < 0.05
- Usual care: type II C/Fi declined −20% ± 21%
- P < 0.05
- Resistance exercise training: type I C/Fi increased +18% ± 14%
- P < 0.05
Myonuclear content · 20 weeks
- Resistance exercise training: type I myonuclear content +24% ± 33%
- P < 0.05
- Resistance exercise training: type II myonuclear content +21% ± 23%
- P < 0.05
Original publication
Resistance Exercise Counteracts the Impact of Androgen Deprivation Therapy on Muscle Characteristics in Cancer Patients. J Clin Endocrinol Metab. Published 10 May 2023. doi:10.
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