Relationship between sRAGE and obesity in individuals with type 1 diabetes during a median follow-up of 6.3 years
Authors' conclusion
sRAGE is inversely associated with both general and central obesity, as represented by BMI and WHtR, independent of kidney disease, suggesting sRAGE is a biomarker of obesity. However, sRAGE is not associated with the changes in BMI and WHtR over a 6.3 year follow-up. Future research with longer follow-up is merited to understand how sRAGE correlates with body fat accumulation.
Study context
- Population
- Adults with T1D from the FinnDiane study
- Participants
- 3,886 adults
- Outcome
- Associations between sRAGE and obesity (BMI; WHtR)
- Follow-up
- Median 6.3 years
Methodological detailsFinnDiane study, linear regression adjusted for sex, age, albuminuria and HbA1c
- FinnDiane study
- Linear regression adjusted for sex, age, albuminuria and HbA1c
Main finding
As reported in the abstract
baseline
- Baseline sRAGE vs BMI, inverse association: r2=0.07, β −0.174
- p<0.001
- Baseline sRAGE vs waist/height ratio (WHtR), inverse association: r2=0.16, β −0.179
- p<0.001
Observational data: associations, not effects.
Further findings
Change in BMI and WHtR · median follow-up 6.3 years
- BMI median Δ 0.76 kg/m² (IQR −0.39 to 2.07)
- P < 0.001
- WHtR median Δ 0.019 (IQR −0.007 to 0.05)
- P < 0.001
- Change in BMI observed in
- 67%
- Change in WHtR observed in
- 68%
sRAGE–BMI/WHtR association by albuminuria subgroup (no, moderate, severe) · baseline
- Relationships remained consistent across subgroups
- all p<0.001
Original publication
Relationship between sRAGE and obesity in individuals with type 1 diabetes during a median follow-up of 6.3 years. Diabetologia. Published 29 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →