HLA haplotype diversity, islet autoantibody status and discriminative ability of type 1 diabetes genetic risk score in Indians
Authors' conclusion
We confirm broad applicability of European 67SNPs T1DGRS to Indian T1D persons. However, differences in HLA allele frequencies, magnitude and directional differences reduced the predictive value. Our results stress the need to generate ancestry-specific GRS, which we plan to do in the near future.
Study context
- Population
- Indians with clinically diagnosed T1D or T2D and non-diabetic controls
- Participants
- 611 / 1,153 / 321
- Comparison
- 67SNPs European T1D genetic risk score: T1D vs T2D and controls; Indians vs Europeans
- T1Dn = 611
- T2Dn = 1,153reference
- Controlsn = 321reference
- Outcome
- Discriminative ability of 67SNPs European T1DGRS (ROC AUC)
Performance
As reported in the abstract
Discrimination of T1D by T1DGRS (AUC)
AUC, Europeans
0.92
AUC, Indians all T1D
0.83
AUC, Indians AA-positive T1D
0.86
Further findings
| Outcome | AA-positive | AA-negative | P value |
|---|---|---|---|
| T1DGRS by islet autoantibody statusHigher in AA-positive | 13.01 (interval 12.79–13.23) | 12.09 (interval 11.64–12.56) | P < 0.0001 |
HLA-DQA1 ~ HLA-DQB1 haplotypes, Indians vs Europeans
- Association of common haplotypes broadly similar; differences in frequency, direction and magnitude of effect for some haplotypes
Original publication
HLA haplotype diversity, islet autoantibody status and discriminative ability of type 1 diabetes genetic risk score in Indians. Diabet Med. Published 25 April 2025. doi:10.
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