Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study
Authors' conclusion
High cumulative TyG index is associated with a higher risk of heart failure. Thus, the TyG index may be useful for the identification of individuals at high risk of heart failure. The present findings emphasize the importance of the long-term monitoring of the TyG index in clinical practice.
Study context
- Population
- Kailuan Study participants with 3 consecutive health examinations (2006, 2008, 2010), no history of HF or cancer
- Participants
- 56,149 participants
- Exposure
- Cumulative TyG index quartiles Q2, Q3, Q4 vs Q1
- Outcome
- New-onset HF
- Follow-up
- To December 31, 2020
Main finding
As reported in the abstract
Risk of HF (adjusted) · median follow-up 10.04 years
Each group vs Q1Hazard ratio (95% CI)
Q2
1.02(0.83,1.25)
Q3
1.29(1.07,1.56)
Q4
1.40(1.15,1.71)
- New HF events
- 1,312
Observational data: associations, not effects.
Further findings
Subgroup analysis
- Significant interaction between cumulative TyG index and BMI or waist circumference; no interaction with age or sex
Sensitivity analysis
- Results consistent with the primary results
Original publication
Relationship between cumulative exposure to triglyceride-glucose index and heart failure: a prospective cohort study. Cardiovasc Diabetol. Published 4 September 2023. doi:10.
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