Reframing Diabetes Mellitus as a Multiaxial Disease Continuum: The Diabetes Severity Classification ( Diabetes Severity Classification (DSC) ) Framework
Authors' conclusion
Conceptually aligned with established staging systems in other chronic diseases, such as the cardiovascular-kidney-metabolic framework, the DSC offers a standardised language to bridge pathophysiology and clinical decision-making, supporting a more individualised and prevention-oriented approach to diabetes care.
Study context
- Population
- All forms of diabetes mellitus (DM)
- Outcome
- Diabetes Severity Classification (DSC) framework
Methodological detailsmultiaxial, stage-based
- Multiaxial
- Stage-based
Main finding
As reported in the abstract
Four interrelated axes: β-cell functional reserve, insulin resistance and metabolic flexibility, glycaemic control, complication burden
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Disease evolution organised into stages, from predisposition to complication-dominant disease
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Original publication
Reframing Diabetes Mellitus as a Multiaxial Disease Continuum: The Diabetes Severity Classification ( DSC ) Framework. Diabetes Obes Metab. Published 9 March 2026. doi:10.
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