Reference intervals for serum 11-oxygenated androgens in children
Authors' conclusion
We developed and validated an assay for 11-oxygenated androgens, in addition to four classic androgens and established reference intervals. This enables a comprehensive evaluation of serum androgen status in children with clinical symptoms of hyperandrogenism.
Study context
- Population
- Healthy children aged 0–17 years
- Participants
- 256 children
- Comparison
- Prepubertal vs Pubertal
- Prepubertaln = 133
- Pubertaln = 123
- Outcome
- Reference intervals (2.5th - 97.5th percentiles) for four 11-oxygenated androgens and four classic androgens in serum, by LC-MS/MS
Methodological detailsSensitive LC-MS/MS assay developed and validated; eight serum androgens quantified
- Sensitive LC-MS/MS assay developed and validated; eight serum androgens quantified
Main finding
As reported in the abstract
- Age-dependency observed for all androgens
- Prepubertal: no significant sex-difference for any measured androgen
- Pubertal: androstenedione, testosterone and dihydrotestosterone differed significantly between boys and girls
- Pubertal: DHEA, 11-hydroxyandrostenedione, 11-ketoandrostenedione, 11-hydroxytestosterone and 11-ketotestosterone did not differ by sex
Original publication
Reference intervals for serum 11-oxygenated androgens in children. Eur J Endocrinol. Published 19 January 2024. doi:10.
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