Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition
Authors' conclusion
These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis.
Study context
- Population
- Patients with anti-PIT-1 hypophysitis, including a new case after ICI therapy
- Participants
- 9 patients
- Outcome
- Clinical features of anti-PIT-1 hypophysitis
Methodological detailscomprehensive analysis of all reported cases, new case report
- Comprehensive analysis of all reported cases
- New case report
Main finding
As reported in the abstract
- Extremely low growth hormone (GH), prolactin (PRL) and thyroid-stimulating hormone (TSH) levels
- 9 patients (all)
- Slightly atrophic pituitary gland
- 2
- Thymoma
- 4
- Malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins
- 5
- HLA-A*24:02 and/or A*02:06 present
- 6
- DR53 present
- 5 cases analyzed
Observational data: associations, not effects.
Original publication
Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition. Eur J Endocrinol. Published 26 December 2023. doi:10.
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