Reduced Insulin Clearance Differently Relates to Increased Liver Lipid Content and Worse Glycemic Control in Recent-Onset Type 2 and Type 1 Diabetes
Authors' conclusion
Insulin clearance is reduced in both T1D and T2D within the first year after diagnosis but correlates negatively with liver lipid content rather in T2D. Moreover, insulin clearance differently associates with glycemic control and insulin sensitivity in each diabetes type, which may suggest specific mechanisms affecting insulin kinetics.
Study context
- Population
- German Diabetes Study (GDS) participants with recent-onset diabetes (T1D, T2D) or normal glucose tolerance
- Participants
- 306 / 489 / 167
- Exposure
- Recent-onset T1D and T2D vs normal glucose tolerance
- T1Dn = 306
- T2Dn = 489
- CONn = 167reference
- Outcome
- Insulin clearance (ICCLAMP, ICIVGTT, ICMMT) and its possible determinants
Methodological detailsGerman Diabetes Study (GDS) cohort, hyperinsulinemic-euglycemic clamps, 1H-MRS
- German Diabetes Study (GDS) cohort
- Hyperinsulinemic-euglycemic clamps
- 1H-MRS
Main finding
As reported in the abstract
T1D vs CON: all P < 0.05 · T2D vs CON: all P < 0.05
Observational data: associations, not effects.
Further findings
Insulin clearance during mixed-meal test (ICMMT) — T1D vs CON · lower in T1D
all P < 0.05
| Outcome | P value |
|---|---|
| Insulin clearance during mixed-meal test (ICMMT)T2D vs CON · lower in T2D | all P < 0.05 |
Insulin clearance vs HbA1c in T1D
- In T1D, ICCLAMP, ICIVGTT and ICMMT correlated negatively with HbA1c (all P < 0.05)
M value vs insulin clearance
- M value vs ICIVGTT in CON (P < 0.05)
- r = 0.199
- M value vs ICIVGTT in T2D (P < 0.05)
- r = 0.178
- M value vs ICMMT in CON (P < 0.05)
- r = 0.176
HCL vs insulin clearance
- HCL vs ICIVGTT in T2D
- r = −0.005
- HCL vs ICMMT in T2D
- r = −0.037
- HCL vs ICIVGTT in CON
- r = −0.127
- HCL vs ICMMT in CON
- r = −0.058
- All P < 0.05
ICMMT by steatosis
- T2D or CON subjects with steatosis had lower ICMMT than those without (both P < 0.05)
Original publication
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