Reduced breast cancer risk in women with a history of pre-eclampsia: implications of postmenopausal hormone therapy
Main finding · Breast cancerResult — go to the resultAdjusted hazard ratio 0.89 95% CI 0.83–0.94Authors' conclusion
BC risk is reduced in women with a history of pre-eclampsia. The MHT-associated increase in BC risk is similar among women with or without a history of pre-eclampsia.
Study context
- Population
- Women who had given birth in 1969–1993, Finland; follow-up for breast cancer (BC) (Finnish Cancer Register 1987–2023) and menopausal hormone therapy (MHT) use (National Reimbursement Register 1994–2019)age-matched cohort
- Participants
- 31,688 vs 91,726
- Exposure
- Prior pre-eclampsia vs no pre-eclampsia; MHT users vs non-users
- Prior pre-eclampsian = 31,688
- Controlsn = 91,726reference
- Outcome
- BC risk
Methodological detailsnationwide, population-based, age-matched
- Nationwide
- Population-based
- Age-matched
Main finding
Breast cancer
Adjusted hazard ratio
0.89
95% CI 0.83–0.94
Events by group
Prior pre-eclampsiavs Controls
aHR 0.89 (95% CI 0.83–0.94)
As reported in the abstract
Observational data: associations, not effects.
Further findings
BC risk with MHT use, by pre-eclampsia history
- MHT use: BC risk rise in prior pre-eclamptic women
- 1.25, 1.12-1.40
- MHT use: BC risk rise in control women
- 1.30, 1.18-1.42
- Comparable MHT-associated BC risk rise in prior pre-eclamptic and control women
- Increased risk with any MHT use seen in both cohorts already after 5 years
- Primarily associated with estrogen-progestogen use; estrogen only not associated with BC risk in prior pre-eclamptic women
Clinical characteristics of pre-eclamptic pregnancy (e.g. severity)
- No clinical characteristic predicted the magnitude of BC risk reduction
Original publication
Reduced breast cancer risk in women with a history of pre-eclampsia: implications of postmenopausal hormone therapy. J Clin Endocrinol Metab. Published 18 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →