Real‐World Weight Loss Is Associated With a Reduction in Cancer Risk
Authors' conclusion
Real-world weight loss was associated with a decreased risk of obesity-related and other cancers.
Study context
- Population
- Adults with BMI ≥ 30 from an integrated US health system's electronic health records (2000–2022)
- Participants
- 143,630 adults
- Comparison
- BMI change and incident cancer
- Casesn = 7,703
- Controlsn = 135,927reference
- Outcome
- Risk of diagnosis of obesity-related cancers by BMI change
- Follow-up
- 3-, 5-, and 10-year intervals
Methodological detailsmatched controls, electronic health records, integrated US health system
- Matched controls
- Electronic health records
- Integrated US health system
Main finding
As reported in the abstract
Obesity-related cancer risk per 1% BMI reduction
Per 1% BMI reductionOdds ratio (95% CI)P value
3 years
0.990(0.984–0.996)
P < 0.0015 years
0.989(0.984–0.995)
P < 0.00110 years
0.992(0.984–1.000)
P = 0.057Per 1% BMI reduction, as printed
Observational data: associations, not effects.
Further findings
Other cancer types per 1% BMI reduction · all intervals
- Similar associations for other cancer types across all intervals
- OR < 1; p < 0.001
Original publication
Real‐World Weight Loss Is Associated With a Reduction in Cancer Risk. Obesity (Silver Spring). Published 10 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →